SNCA


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Related to SNCA: SNAC, SBCA

SNCA

A gene on chromosome 4q21 that encodes alpha synuclein, which may be involved in regulating dopamine release and transport. SNCA induces fibrillisation of microtubule-associated protein tau, reduces neuronal responsiveness to apoptotic stimuli, and downregulates caspase-3.
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References in periodicals archive ?
Despite these limitations, our study is the first to provide evidence that festination is associated with SNCA polymorphism at rs11931074 or rs894278.
The SNCA gene is located on human chromosome 4 and encodes the protein alpha-synuclein.
The relationship between [alpha]-synuclein and PD was established with the identification of specific mutations in the SNCA gene encoding for [alpha]-synuclein, in families with PD.
Although several genes have been related to the development of nonmotor signs of PD in humans (e.g., SNCA, LRRK2, VPS35, and Parkin), only a few studies have explored the influence of these mutations on depressive-like behavior in mice [62].
Nineteen years ago, the discovery of the first genetic mutation responsible for Parkinson's disease (PD), p.A53T in the [alpha]-synuclein (SNCA) gene [1], provided the initial insights into the molecular genetics of PD.