ABCC5

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ABCC5

A gene on chromosome 3q27 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC5 exports its substrate, cyclic nucleotides, contributing to the degradation of phosphodiesterases, and may be an elimination pathway for cyclic nucleotides. ABCC5 is linked to resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, in patients with acute lymphocytic leukaemia, and resistance to antiretroviral nucleoside analogues (e.g., 9-(2-phosphonylmethoxyethyl)adenine) in HIV-infected patients.
References in periodicals archive ?
To date, the most important biomarkers in MPM diagnosis and prognosis were SMRP and OPN, as shown by several authors in the research field [4, 6, 12, 13].
Serum SMRP levels were detected by ELISA (Mesomark; Fujirebio Diagnostics, USA); the test was performed according to the manufacturer's instructions.
(44) As with the SMRP, the success rate, measured in terms of appearance, was high; a compliance rate of seventy-six percent was reported over a six-year period with over 1,700 persons released.
"The state of the art of maintenance in North America," Proceedings of the 8th Annual Conference of the Society for Maintenance & Reliability Professionals, SMRP, Knoxville, 2000.
A solution to an SMRP is an allocation that maps destination cells to nonoverlapping portions of source cells or to new memory.
Mumbai/Singapore: Fitch Ratings expects Netherlands-based Samvardhana Motherson Automotive Systems Group BV's (SMRP BV, BB+/Positive) credit profile to benefit from its proposed acquisition of Reydel Automotive Group (Reydel) because the transaction is moderately sized and neutral to SMRP BV's leverage, and will enhance its business diversification.
SMRP Research Paper 91, Dept, of Geophysical Sciences, University of Chicago, 42 pp.
He is also a member of the International Facilities Management Association (IFMA) and the Society for Maintenance & Reliability Professionals (SMRP).
Since July 2010, SMRP has invested more than $9 million in recycling programs.
The mesothelin gene is located on chromosome 16p13.3 and encodes at least four protein products, including megakaryocyte potentiating factor (MPF) [13, 14] and three isoforms of mesothelin, which are variant 1 (mesothelin) [14], the currently uncharacterized variant 2 [15, 16], and variant 3 (soluble-mesothelin-related protein (SMRP)) [17].
The Women's Secretariat (SMRP) ran one shelter for female trafficking victims in Asuncion that did not detain adult victims involuntarily.
Despite the expression of membrane-bound mesothelin in different tumors, these soluble mesothelin-related peptides (SMRP) have proven to be a promising cancer biomarker in the sera of patients with tumors of mesothelial origin (7,10).