SHH

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SHH

A gene on chromosome 7q36 that encodes a protein central in early embryonic patterning and the key inductive signal in patterning of the anterior-posterior limb axis, the ventral somites and the ventral neural tube.

Molecular pathology
Defects in SHH or in its signalling pathway cause holoprosencephaly, VACTERL syndrome; mutation upstream of SHH disrupts limb patterning and can result in preaxial polydactyly.
References in periodicals archive ?
Yulo said SMMCI's MPSA 'was issued following all relevant legal requirements and procedures, including regulatory clearance, that the area covered by the MPSA is open to mining.
24, SMMCI chief finance officer Jerome Jovellana told Lopez that, first, there was no legal basis for the MPSA cancellation.
11, 2010, SMMCI filed a petition for corporate rehabilitation.
SMMCI further claimed that while several persons signified interest in investing in SMMCI, they needed enough time for audit and due diligence.