HDAC3(redirected from SMAP45)
HDAC3A gene on chromosome 5q31 that encodes histone deacetylase 3; it belongs to the histone deacetylase/acuc/apha family, which represses transcription when tethered to a promoter and may regulate transcription by binding with the zinc-finger transcription factor YY1. HDAC3 downregulates p53 activity and thus modulates cell growth and apoptosis; it may be a tumour suppressor gene.
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