SMAD7

SMAD7

A gene on chromosome 18q21.1 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD7 is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Once bound, the complex translocates to the cytoplasm, where it inhibits TGF(transforming growth factor)-beta and activin signalling by associating with their receptors, preventing SMAD2 access.
 
Molecular pathology
SMAD7 variants have an increased susceptibility to colorectal cancer type 3.
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References in periodicals archive ?
Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase.
M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7.
TGF-[beta] and NF-[kappa]B signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers.
By inhibiting production of a compound called SMAD7, it restores the activity of an immune-calming protein called transforming growth factor beta 1, which suppresses TNF-alpha, researchers report in the March 19 New England Journal of Medicine.
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.
III] Arachidonate 5-lipoxygenase- ALOX5AP Leukotriene activating protein biosynthesis SMAD, mothers against DPP SMAD7 Transforming growth homolog 7 (Drosophila) factor beta receptor, inhibitory cytoplasmic mediator activity Transcription factor 12 TCF12 Regulation of transcription Gene names and symbols are from UniGene (http://www.