SMAD4


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SMAD4

A gene on chromosome 18q21.1 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD4 forms homomeric complexes and heteromeric complexes with other activated SMADs; these accumulate in the nucleus and regulate target gene transcription. SMAD4 binds to DNA and recognizes an 8-bp palindromic sequence, the SMAD-binding element (SBE).
 
Molecular pathology
SMAD4 mutations or deletions are linked to hereditary haemorrhagic telangiectasia syndrome, juvenile polyposis syndrome and pancreatic cancer.
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References in periodicals archive ?
USP9x hydrolyzes Smad4 monoubiquitination [95-97], enhancing TGF-[beta] signal.
The primary aim of this study was to examine the protein expression levels of SMAD4 in mucosal biopsies obtained from the terminal ileum of patients with CD and to correlate the expression levels with CD activity.
SMAD7 also interferes with R-SMAD4 complex formation by competing with SMAD4 to interact with R-SMADs [65, 66].
In silico analysis of SMAD4 involved in hepatocellular carcinoma.
Our results corroborate these findings as we observed an increase in gene expression of LTPB1, TGFpl, SMAD2, SMAD4, COL1A1, COL1A2, COL6A3, MMP1, MMP2, MMP3, and MMP4.
Although the SMAD4 gene was mutated in the tumor, it was not mutated in the blood sample, and BMPR1 gene mutations were not found either.
The membranes were blocked for 2 h at room temperature with 5% skimmed milk or 5% BSA in TBST and then were probed with a STAT3 antibody, phospho-STAT3-(Tyr705-) antibody, SMAD4 antibody, phospho-JAK2 antibody, phospho-SMAD1/5/8 antibody, NF-[kappa]B p65 antibody, phospho-I[kappa]B[alpha] antibody, IKK[alpha] antibody, SOCS3 antibody, Id1 antibody, BMP6 antibody, ferroportin antibody, ferritin antibody, and hepcidin antibody.
SMAD4. SMAD4 is an oncosuppressor protein that intervenes in the intracellular pathway of TGF-[beta].
Different ligands can bind to TGF-[sz] receptors on the cell surface, allowing regulatory messages to be transferred into the cell by activating the signaling effectors and the Sma- and Mad-related proteins (Smads) and ultimately interacting with deoxyribonucleic acid.[sup][7] Both Smad2 and Smad3 are activated by TGF-[sz], myostatin, or activin whereas Smad1, Smad5, and Smad8 are activated by bone morphogenetic proteins; the activation of these proteins results in the interaction with Smad4, leading to the modulation of target gene expression.
La activacion de estos Smads, permite la traslocacion de Smad4 del citoplasma al nucleo para la regulacion de la transcripcion genica.
Resveratrol selectively induces DNA Damage, independent of Smad4 expression, in its efficacy against human head and neck squamous cell carcinoma.