SMAD1


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SMAD1

A gene on chromosome 4q31.21 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (Mad), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD1 mediates signals from bone morphogenetic proteins (BMPs), which mediate an array of biological activities, including cell growth, apoptosis, morphogenesis, development and immune responses. In response to the binding of BMP ligands, SMAD is phosphorylated and activated by the BMP receptor kinase; phosphorylated SMAD1 forms a complex with SMAD4, resulting in transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases—SMURF1 and SMURF2. Its activity is downregulated by ubiquitination and proteasome-mediated degradation.
References in periodicals archive ?
Moreover, they identified that the intracellular signaling protein SMAD1 plays a critical role in this process.
Twist1-related miR26b-5p suppresses epithelial-mesenchymal transition, migration and invasion by targeting SMAD1 in hepatocellular carcinoma.
Besides, of the nine SMAD protein that were found, SMAD5 and SMAD1 are involved in the signal transduction of BMP (Hild et al.
Posterior a esto se da la fosforilacion del receptor tipo I de la BMP, mediante el receptor tipo II, y asi se activa la via SMAD1, 5 y 8.
The action of BMP-2 is mediated by heterotetrameric serine/threonine kinase receptors and the downstream transcription factors SMAD1, 5, 8.