SMAD5

(redirected from SMAD family member 5)

SMAD5

A gene on chromosome 5q31 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD5 is a receptor-regulated SMAD (R-SMAD) transcriptional modulator activated by bone morphogenetic protein (BMP) type-1 receptor kinase.
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Gene Af1, presented a higher expression in antler mesenchyme of female reindeer than the male reindeer, was found to share a high homology (95%) with the Ovis aries SMAD family member 5 (SMAD5) that related to transforming growth factor (TGF-ss).