SMAD3

(redirected from SMAD family member 3)

SMAD3

A gene on chromosome 15q22.33 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD3 mediates the signal of transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes—e.g., cell proliferation, apoptosis and differentiation. SMAD3 binds to TRE in the promoter of many genes regulated by TGF-beta and forms a complex with SMAD4, resulting in transcription regulation.
References in periodicals archive ?
It was shown that GRHL2 interferes with TGF-[beta] signaling by repressing the ZEB1 promoter and by interfering with SMAD family member 2 (SMAD2)- and SMAD family member 3 (SMAD 3)-mediated transcriptional activation (27).
In a complex with CDK4 it phosphorylates and inhibits retinoblastoma 1 (RB1) protein to control the restriction point of the cell cycle); AHR, aryl hydrocarbon receptor (aryl hydrocarbon receptor is an intracellular ligand activated receptor and transcription factor, and regulates xenobiotic-metabolizing enzymes expression); SMAD2, SMAD family member 2; SMAD3, SMAD family member 3 SMAD family members are intracellular signal transducers and mediate the signal of TGF-[beta].