SMAD6

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SMAD6

A gene on chromosome 15q21-q22 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD6 downregulates BMP and TGF-beta/activin-signalling by binding to regulatory elements in target promoter regions.
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SMAD proteins the major intracellular signal transducers for the TGF-AY family receptors can be divided into three types: receptor-regulated SMADs (R-SMADs: SMAD 1 2 3 5 and 8) inhibitory SMADs (I-SMADs: SMAD 6 and 7) and a common-mediator SMAD (SMAD4) (Cai et al.