NLRP1

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NLRP1

A gene located on chromosome 17p13.2 that encodes a member of the Ced-4 family of apoptosis proteins, which contain a caspase recruitment domain (CARD) and are key mediators of apoptosis. NLRP1 (formerly, NALP1) stimulates apoptosis by activating caspase-3.
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Various susceptibility loci are AIS1 (chr1), AIS2 (chr7), AIS3 (chr8), SLEV1 (chr17), VIT 1 GENE on chromosome 2p16 and gene NALP1 on chromosome 17p13.