SLCO2A1


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SLCO2A1

A gene on chromosome 3q21 that encodes a transporter which mediates the release, transepithelial transport, and clearance of newly synthesised prostaglandins (PGD2, PGE1, PGE2 and PGF2A) from the circulation.

Molecular pathology
Defects in SLCO2A1 cause hypertrophic osteoarthropathy, primary, autosomal recessive type 2.
References in periodicals archive ?
ABCC4 and SLCO2A1 mRNAs are expressed in a stage and cell type specific manner in the uterine endometrium during pregnancy, and their expression is increased by interleukin-1[beta] (IL1B) during the implantation period [8].
Our previous study has shown that the patterns of ABCC4 and SLCO2A1 expression during pregnancy were biphasic with the highest levels on D12 and D90 of pregnancy [8].
Expression of ABCC4 and SLCO2A1 mRNA and protein has also been shown in conceptus tissues and chorioallaltoic tissues [8].
However, expression of ABCC1 and ABCC9 mRNAs was not detected in endothelial cells of endometrial blood vessels, which express SLCO2A1 [8].
Results of this study showed that levels of ABCC1 and SLCO2A1 mRNA were significantly higher on D12 of pregnancy than the estrous cycle and levels of ABCC9 and SLCO4C1 mRNA were higher during pregnancy than during the estrous cycle.
Our previous study has also shown that IL1B, but not estrogen, increases the expression of ABCC4 and SLCO2A1 mRNAs, which show higher levels of endometrial expression on D12 of pregnancy than during the estrous cycle in pigs [8].