SLCO1B1

SLCO1B1

A gene on chromosome 12p12 that encodes a transporter which mediates Na+-independent uptake of organic anions—e.g., pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl oestradiol, oestrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. SLCO1B1 may play a key role in clearing bile acids and organic anions from the liver.

Molecular pathology
Defects in SLCO1B1 are a cause of Rotor syndrome.
References in periodicals archive ?
Solute carrier organic anion transporter family, member 1B1 (SLCO1B1) gene encodes the statins influx transporter, an organic anion-transporting polypeptide 1B1 (OATP1B1).
CYP3A5, ABCB1 and SLCO1B1 Polymorphisms and Pharmacokinetics and Virologic Outcome of Lopinavir/Ritonavir in HIV-infected Children.
The human organic anion transporting polypeptide 1B1 (OATP1B1) (gene symbol SLCO1B1, previously OaTP2, OATP-C, and LST-1) [4] is expressed solely on the basolateral membrane of hepatocytes, facilitating the uptake of clinically relevant compounds such as antibacterial drugs, statins, and chemotherapeutic drugs [5].
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) is one of the organic anion transporters and localized at the sinusoidal membrane of hepatocytes, and its transcript has been detected in enterocytes.
2007), we demonstrated that transfection of OATP1B1 (SLCO1B1) or OATP1B3 (SLCO1B3) cDNA into HEK293 cells increased their sensitivity to, and their accumulation of, microcystin-LR and, consequently, induced apoptosis in those cells.
(34.) SEARCH Collaborative Group, SLCO1B1 Variants and Statin Induced Myopathy--A Genomewide Study, 359 NEW ENG.
Genomewide association studies showed a strong correlation with a variant form of the gene SLCO1B1. The risk of myopathy was 18% among homozygotes for the high-risk allele and 2% for heterozygotes (one copy of the high-risk and one copy of the low-risk allele).
They found a strong association of myopathy with single-nucleotide polymorphism located within the SLCO1B1 gene.
As the role of SLCO1B1 gene (encodes OATP1B1 or liver specific transporter-1) 388 A>G polymorphism in susceptibility towards gallstone disease is unclear the prevalence of this polymorphism in healthy north Indian population was investigated.
A variant form of the gene SLCO1B1 may be responsible for muscle pain that statins sometimes cause (SN: 8/16/08, p.