Solute carrier organic anion transporter family, member 1B1 (SLCO1B1
) gene encodes the statins influx transporter, an organic anion-transporting polypeptide 1B1 (OATP1B1).
CYP3A5, ABCB1 and SLCO1B1
Polymorphisms and Pharmacokinetics and Virologic Outcome of Lopinavir/Ritonavir in HIV-infected Children.
The human organic anion transporting polypeptide 1B1 (OATP1B1) (gene symbol SLCO1B1
, previously OaTP2, OATP-C, and LST-1)  is expressed solely on the basolateral membrane of hepatocytes, facilitating the uptake of clinically relevant compounds such as antibacterial drugs, statins, and chemotherapeutic drugs .
Solute carrier organic anion transporter family member 1B1 (SLCO1B1
) is one of the organic anion transporters and localized at the sinusoidal membrane of hepatocytes, and its transcript has been detected in enterocytes.
2007), we demonstrated that transfection of OATP1B1 (SLCO1B1
) or OATP1B3 (SLCO1B3) cDNA into HEK293 cells increased their sensitivity to, and their accumulation of, microcystin-LR and, consequently, induced apoptosis in those cells.
(34.) SEARCH Collaborative Group, SLCO1B1
Variants and Statin Induced Myopathy--A Genomewide Study, 359 NEW ENG.
Genomewide association studies showed a strong correlation with a variant form of the gene SLCO1B1
. The risk of myopathy was 18% among homozygotes for the high-risk allele and 2% for heterozygotes (one copy of the high-risk and one copy of the low-risk allele).
They found a strong association of myopathy with single-nucleotide polymorphism located within the SLCO1B1
As the role of SLCO1B1
gene (encodes OATP1B1 or liver specific transporter-1) 388 A>G polymorphism in susceptibility towards gallstone disease is unclear the prevalence of this polymorphism in healthy north Indian population was investigated.
A variant form of the gene SLCO1B1
may be responsible for muscle pain that statins sometimes cause (SN: 8/16/08, p.