SLCO1A2

SLCO1A2

A gene on chromosome 12p12 that encodes a solute transporter that mediates the Na+-independent transport of organic anions such as sulfobromophthalein and conjugated (taurocholate) and unconjugated (cholate) bile acids. It is selectively inhibited by naringin in grapefruit juice.
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References in periodicals archive ?
OATP1A2 (gene symbol, SLCO1A2) mediates the cellular uptake of a wide range of endogenous substrates including estrogen conjugates, DHEAS, thyroid hormones, prostaglandins, and bile acids.
This is suggested from the finding that SLCO1A2 mutations influence the imatinib clearance in patients with chronic myeloid leukemia [42].
Kullak-Ublick, "The SLCO1A2 gene, encoding human organic anion-transporting polypeptide 1A2, is transactivated by the vitamin D receptor,", Molecular Pharmacology, vol.