is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.
The SLC2A9 gene provides instructions for making a protein called glucose transporter 9 (GLUT9).
[while] the role of the SLC2A9 gene in gout may be unclear, it is known that a combination of lifestyle, genetic, and environmental factors play a part in determining the risk of this complex disorder.
Genetic variants in several genes have been associated with plasma urate, however, variation in solute carrier family 2 member 9 (SLC2A9) is the major genetic determinant for plasma urate (3, 12, 16).
Second, we investigated whether SLC2A9 rs7442295, a genetic variant in the GLUT9 urate transporter, was associated with high plasma urate in the same population and furthermore used this genetic variant to test if genetically determined high concentrations of urate were associated with high cancer incidence and all-cause mortality to infer causality.
is considered to be the most effective urate transporter , affecting circulating uric acid levels.
used a single nucleotide polymorphism of the SLC2A9
urate transporter gene to evaluate the effects of hyperuricemia on ischemic heart disease and found no association .
Proksimal tubuldeki urat transportunu kodlayan, hem SLC22Al2 hem de SLC2A9
genlerindeki mutasyonlar olusum nedenleri olarak Hiperurikozurinin diger nedenleri, fazla purin alum (hayvansal protein), hemoliz, uikozurik ilaclar (probenesid, salisilatlar ve losartan).
In addition to these observations, Vitart and associates have recently identified a novel renal urate transporter, SLC2A9
, whose genetic variants appear to influence serum urate concentrations.
(4) One such critically important region that has been identified is the SLC2A9
locus located on chromosome 4 of the human genome.
The work in this exhibition was made in conjunction with Padmini Parthasarathy, from the Department of Biochemistry who is currently researching the SLC2A9