SLC2A4

SLC2A4

A gene on chromosome 17p13 that encodes insulin-responsive glucose transporter type 4, a plasma membrane that mediates facilitated glucose transport.

Molecular pathology
SLC2A4 mutations are associated with type-2 (non-insulin-dependent) diabetes.
References in periodicals archive ?
INPP4A PIK3R1 10097090 TAFIA CD3EAP 15226435 GHR PIK3R1 9632636 MAPK8 PIK3R1 7642542 PTK2B PIK3R1 10797305 SLC2A4 CTSD 16396496 CRKL PIK3R1 9461587 With these two nodes provided, their edge is implied.
Although lipophilic, atorvastatin can improve insulin sensitivity in an obese mice model [97], through an increase in mRNA and protein expression of the slc2a4 gene (which codifies GLUT4) and a decrease in mRNA and protein expression of IL6 in subcutaneous AT (SCAT) [97].
Relative Gene Expression Analysis for Slc2a4 (Glut4) and Acss2 (AceCS1).
The mRNA levels for Glut4 (Slc2a4 gene) were also altered (P < 0.05).
Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes.
ZNF395 is conserved to two other proteins, which are the SLC2A4 regulator (SLC2A4RG, also known as Glut4 enhancer binding protein (GLUT4EF) or HDBP1) and ZNF704 (also known as glucocorticoid induced gene 1 (GIG1)).
This review summarizes the potential participation of miRNAs in the regulation of GLUT4 protein (codified by the SLC2A4 gene) and proteins related to its translocation, in skeletal muscle, exploring their involvement in the pathophysiology of diabetes, as well as their potential role in preventive or therapeutic approaches for diabetes.
The GLUT4 protein (codified by the gene solute carrier family 2 member 4, SLC2A4) is the major glucose transporter of brown and white adipose tissues and of skeletal and cardiac muscles [21].
RT-PCR was performed using Roche FastStart DNA Master HybProbe (Roche) and Taqman primers and probes for fatty acid synthase (FASN; Hs01005622), glycerol-3-phosphate acyltransferase (GPAM; Hs0157368), solute carrier family 2, member 1 (GLUT1, also known as SLC2A1; Hs0089268), Solute Carrier Family 2, member 4 (GLUT4, also known as SLC2A4; Hs00168966), Solute Carrier Family 2, member 5 (GLUT5, also known as SLC2A5; Hs0016172), adiponectin (Hs00605917), leptin (Hs00174877), and interleukin 6 (IL6; Hs00985639) obtained from Life Technologies.
GLUT4 (SLC2A4, facilitated glucose transporter, member 4) is the mainly glucose transporter expressed in skeletal muscle.
Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control.
Yada, "Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control," Diabetologia, vol.