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Unconjugated BS are transported by the multispecific ATP- and [Na.sup.+]-independent basolateral uptake transporters, organic anion-transporting polypeptide 1B1 (OATP1B1, also termed OATP-C, OATP2, SLC21A6, or LST-1, encoded by SLCO1B1), and 1B3 (OATP1B3, synonyms OATP8, SLC21A8, or LST3, encoded by SLCO1B3) [4, 7, 8].