Unconjugated BS are transported by the multispecific ATP- and [Na.sup.+]-independent basolateral uptake transporters, organic anion-transporting polypeptide 1B1 (OATP1B1, also termed OATP-C, OATP2, SLC21A6
, or LST-1, encoded by SLCO1B1), and 1B3 (OATP1B3, synonyms OATP8, SLC21A8, or LST3, encoded by SLCO1B3) [4, 7, 8].
The best-studied genetic contributor to statin-induced side effects is SLCO1B1 (also referred to as SLC21A6
, OATP-C, or OATP1B1), which codes for a hepatic drug transporter that mediates the hepatic uptake of statins.
Kim, "Human organic anion transporting polypeptide-C (SLC21A6
) is a major determinant of rifampin-mediated pregnane X receptor activation," Journal of Pharmacology and Experimental Therapeutics, vol.
A Naturally Occurring Mutation in the SLC21A6 Gene Causing Impaired Membrane Localization of the Hepatocyte Uptake Transporter.
Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics.
Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.
Polymorphisms of OATP-C (SLC21A6
) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.