SLCO1B1

(redirected from SLC21A6)

SLCO1B1

A gene on chromosome 12p12 that encodes a transporter which mediates Na+-independent uptake of organic anions—e.g., pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl oestradiol, oestrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. SLCO1B1 may play a key role in clearing bile acids and organic anions from the liver.

Molecular pathology
Defects in SLCO1B1 are a cause of Rotor syndrome.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Unconjugated BS are transported by the multispecific ATP- and [Na.sup.+]-independent basolateral uptake transporters, organic anion-transporting polypeptide 1B1 (OATP1B1, also termed OATP-C, OATP2, SLC21A6, or LST-1, encoded by SLCO1B1), and 1B3 (OATP1B3, synonyms OATP8, SLC21A8, or LST3, encoded by SLCO1B3) [4, 7, 8].
The best-studied genetic contributor to statin-induced side effects is SLCO1B1 (also referred to as SLC21A6, OATP-C, or OATP1B1), which codes for a hepatic drug transporter that mediates the hepatic uptake of statins.
Kim, "Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation," Journal of Pharmacology and Experimental Therapeutics, vol.
A Naturally Occurring Mutation in the SLC21A6 Gene Causing Impaired Membrane Localization of the Hepatocyte Uptake Transporter.
Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics.
Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.