SLC1A3

SLC1A3

A gene on chromosome 5p13 that encodes solute carrier family 1 member 3, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters clear the excitatory neurotransmitter glutamate from the extracellular space at synapses in the CNS and maintain extracellular glutamate concentrations below neurotoxic levels.
 
Molecular biology
SLC1A3 mutations are associated with episodic ataxia, Type 6.
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Genetic analysis was performed on 18 genes, including KCNA1, CACNA1A, CACNB4, SLC1A3, VAMP1, APTX, SETX, and PNKP.
(1) In short, Gene Ontology analysis has identified several potentially affected pathways involved in synaptic transmission (HTR2A, BDNF, CHRNA3, CHRNB4, DRD1, DRD2, DRD4, EGR1, GRIA4, GRIN2B, GRM3, NISCH, SLC1A3, and ERBB4), dopamine metabolic processes (COMT, DRD1, DRD2, DRD4, MAOA, NR4A2, and SLC6A3), and ion channel activity (CHRNA7, CACNA1I, CACNB2, CHRNA3, CHRNA5, CHRNB4, GABRB3, GRIA4, GRIA1, GRIN2B, HCN1, CACNA1C, KCTD13, KCNV1, KCNN3, KCNJ13, and KCNB1).
It is reported that L-theanine competitively inhibited the uptake of glutamate substrate through solute carrier family 1, member 3 (SLC1a3) and SLC1a2 expressed in cancer cells [12, 13].