These RNA transcripts include TDP-43 itself, FUS, glial excitatory amino acid transporter-2 (EAAT2, solute carrier family 1 member 2 (SLC1A2
), or glutamate transporter 1 (GLT-1)), amyloid beta precursor protein (APP), presenilins, huntingtin, ataxins, synuclein, progranulin, and tau [25, 26].
Due to the overlap phenomena between ET and PD, investigations into the relationship between PD risk variants and ET patients have been done, involving LINGO1, LINGO2, LRRK2, SLC1A2, and HTRA2 genes [3,10-12].
Chen et al., "SLC1A2 variant is associated with essential tremor in taiwanese population," PLoS ONE, vol.
Alonso-Navarro et al., "No association of the SLC1A2 rs3794087 allele with risk for essential tremor in the Spanish population," Pharmacogenetics and Genomics, vol.
ONECUT2 (One Cut Homeobox 2), RC3H1 (Ring Finger and CCCH-Type Domains 1), and SLC1A2
(Solute Carrier Family 1 Member 2) were regulated by 19 upregulated miRNAs; ONECUT2 and RAB6B (Member RAS Oncogene Family) were regulated by 11 downregulated miRNAs.
It is the first evidence that one of the genes, SLC1A2
, can cause epilepsy in humans.
Acidic AA transporters solute carrier family 1, member 1 (SLC1a1) and member 2 (SLC1a2) transport glutamate and aspartate.
Expression of acidic AA transporter SLC1a1 was upregulated in the jejunum and ileum (Quadratic, P < 0.001), while jejunal SLC1a2 transcript was linearly decreased (P < 0.001) with the increasing doses of L-theanine but increased by L-theanine treatments in the ileum (Quadratic, P < 0.05).