SLC1A1

SLC1A1

A gene on chromosome 9p24 that encodes solute carrier family 1 member 1, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters terminate the postsynaptic action of the neurotransmitter glutamate and maintain extracellular glutamate concentrations below neurotoxic levels. SLC1A1 also transports aspartate.

Molecular biology
SLC1A1 loss-of-function mutations cause dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect.
References in periodicals archive ?
One gene, SLC1A1, for example, helps modulate activity of the brain neurotransmitter glutamate, and has been linked to a metabolic disorder associated with intellectual disability and obsessive-compulsive disorder.
Expressions of amino acid transport-related genes, such as SLC1A1, SLC1A5, SLC7A1, SLC7A7, and SLC15A1, were significantly increased by spermine supplementation (Group SP-3 d vs Group Con-3 d; Group SP-6 d vs Group Con-6 d; Group SP-9 d vs Group Con-9 d; p<0.05).
Based on the findings shown in Table 4, spermine supplementation markedly improved the gene expressions of SLC1A1 and SLC7A7 (Group SP-6 d relative to Group Con-6 d; Group SP-9 d relative to Group Con-9 d), SLC1A5 (Group SP-3 d vs Group Con-3 d; Group SP-6 d vs Group Con-6 d; Group SP-9 d vs Group Con-9 d), SLC7A1 (Group SP-6 d relative to Group Con-6 d), SLC7A9 (Group SP-7 h vs Group Con-7 h; Group SP-3 d vs Group Con-3 d; Group SP-6 d vs Group Con-6 d; Group SP-9 d vs Group Con-9 d), and SLC15A1 (Group SP-9 d relative to Group Con-9 d) (p<0.05) and did not influence SLC6A19 mRNA level in the spleen of piglets (p>0.05).
SLC1A1, as a representative glutamate transporter, can provide the substance and energy required for cellular metabolism through adjusting the cellular absorption of glutamate [26].
Focusing on the cell signaling pathway, we particularly notice that EREG [26], SLC1A1 [27], STC2 [28], GAD1 [29], and TRH [30] are genes not selected by the JGGM but nonetheless previously were monitored in signaling pathways.
miRNA ID NOG p value TFP p value miR-145-5p 1 1.66E--02 0.67 2.98E--08 miR-204-5p 5 1.78E--15 0.13 1.05E--02 miR-182-5p 2 1.80E--08 0.20 4.34E--04 miR-567 1 1.66E--02 0.25 4.61E--04 miR-141-3p 2 1.80E--08 0.14 2.05E--03 miR-454-3p 2 1.80E--08 0.11 4.64E--02 miR-590-3p 5 1.78E--15 0.13 2.33E--03 miR-338-3p 2 1.80E--08 0.25 4.61E--04 miR-139-5p 1 1.66E--02 1.00 1.49E--08 miRNA ID Whole target genes miR-145-5p MMP12; ZFP36; KLF4 miR-204-5p DPYSL2; EMP1; SPDEF; LMO7; SLC1A1; ALPL; MMP9; FRAS1 miR-182-5p CAMK2N1; ZFP36; UBE2T; LPHN2; RGS17.
In addition, a novel miRNA (miR-101b) was found to be downregulated in depression and could decrease mRNA and protein levels of glutamate transporter SLC1A1 in the prefrontal cortex [59].
Villaescusa et al., "MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro," International Journal of Neuropsychopharmacology, vol.
Old versus young (fold- Step-up p Gene difference) (a) value (b) Cys and CySS transporters Slc7all# Down 5.0-fold# 0.0034# Slc7a9 0.28 Slc1a1 0.85 Slc1a4 Down 1.5-fold 0.034# Slc1a5 0.092 Slc3a1 0.38 Slc3a2 0.69 Thiol-disulfide enzymes: Glutathione-related Gpx1 Up 1.4-fold 0.033# Gpx2 0.096 Gpx3 0.49 Gpx4 0.064 Gpx5 0.87 Gpx6 0.71 Gpx7 0.067 Gpx8 0.23 Gsr 0.54 Gclc 0.62 Gclm 0.60 Gss 0.48 Glrx Down 1.7-fold 0.0097# Glrx2 0.11 Glrx3 Up 1.4-fold 0.044# Glrx5 Up 1.2-fold 0.048# (a) Fold-difference in expression in old fibroblasts relative to the expression in young fibroblasts is shown for all genes with a significant difference.
Acidic AA transporters solute carrier family 1, member 1 (SLC1a1) and member 2 (SLC1a2) transport glutamate and aspartate.
Expression of acidic AA transporter SLC1a1 was upregulated in the jejunum and ileum (Quadratic, P < 0.001), while jejunal SLC1a2 transcript was linearly decreased (P < 0.001) with the increasing doses of L-theanine but increased by L-theanine treatments in the ileum (Quadratic, P < 0.05).
Although direct evidences about the regulatory mechanism of AA transporters transcription by L-theanine are lacking, previous literatures showed that activating transcription factor 4 (ATF4) could transcriptionally upregulate SLC7a1 [24] and regulatory factor X proteins (RFXs) induced mRNA of SLC1a1 [25].