MMP11

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MMP11

A gene on chromosome 22q11.23 that encodes matrix metalloproteinase 11. Unlike other matrix metalloproteinases, which are secreted as inactive proproteins and activated when cleaved by extracellular proteinases, MMP11 is activated intracellularly by a furin endopeptidase. It cleaves alpha 1-proteinase inhibitor, but only weakly acts on the structural proteins of the extracellular matrix.

Molecular pathology
MMP11 may play a key role in the progression of epithelial malignancies, and is specifically expressed in stromal cells of breast carcinomas.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
He said the government had also approved 2.2 equitythe money that would be returned by the contractor within first 10 years after the construction of the SL-3.
The Rs8bn Ring Road SL-3 will start from Adda Plot (Raiwind Road) and end at Maraka after crossing Multan Road.
Talking about the remaining ring road's sections, he says after completion of SL-3, work on SL-4 and western loop will be launched.