TGFBR1

(redirected from SKR4)

TGFBR1

A gene on chromosome 9q22 that encodes a transmembrane kinase of the TGFB receptor subfamily of Ser/Thr protein kinases, which forms a heteromer with type-II TGF-beta receptors and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which enter the nucleus and regulate transcription of cell proliferation-related genes.

Molecular pathology
TGFBR1 mutations are associated with Loeys-Deitz aortic aneurysm syndrome.
References in periodicals archive ?
Saab Aircraft Saab has won a SKr4.5 billion (USD670 million) contract to supply an undisclosed nation with one Erieye surveillance radar-equipped Saab 2000 airborne early warning and control system aircraft.
Loomis Fargo, which is based in Houston, Texas, employs 2,200 staff and has a fleet of 2,600 vehicles, is expected to post turnover of SKr4.2 billion, according to Securitas.
The figure was not included in the profit forecast published on 12 March, anticipating a pre-tax loss of between SKr4 and 5 billion for the first quarter.
Atle, which is quoted on the Stockholm stock exchange, posted a pre-tax profit of SKr 660 million for the period from January to September 2000, with assets worth SKr4.991 billion.