ACVR1B

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ACVR1B

A gene on chromosome 12q13 that encodes activin receptor type IB, a receptor that forms a complex with other type-I and two type-II  transmembrane serine/threonine kinase receptors for activin, a dimeric growth and differentiating factor belonging to the TGF-beta superfamily of structurally related signalling proteins. Type-II receptors phosphorylate and activate type-I receptors, which autophosphorylate, then bind and activate SMAD transcriptional regulators, playing roles in cell differentiation, growth arrest and apoptosis. 

Molecular pathology
ACVR1B mutations are associated with pituitary tumours.
References in periodicals archive ?
construction of wells cable distribution SKR2 of concrete blocks 2 stud.
Saab Aircraft Saab has received a four-year contract worth SKr2 billion (USD280 million) to improve the Swedish air force's Gripen C/D fighters.
Electrolux, the Swedish domestic appliances giant, has announced the acquisition for SKr2.5 billion (Euro 281 million) of the Australian Email group's "white goods" division (refrigerators, washing machines, dish washers, etc.).
Telia was first and reduced the price from SKR2.50 to SKR0.80 per minute, a reduction of 68%.
Framtidsfabriken was the larger of the two founding companies, with a net profit of SKr14.5m ($1.7m) on revenue of SKr100m ($12m) last year, while Netsolutions had SKr2.5m ($300,000) on revenue of SKr44m ($5.2M).
The SKr2.86 billion budget for 1993 included SKr500 million not used in previous years.
The Swedish group, which last year posted sales of SKr2 billion (Euro 231 million) in Australia, recently announced a 7% decline in its net profits after 9 months to SKr2.722 billion, while turnover rose 9% to SKr 31.81 billion.