MAP2K6

(redirected from SKK3)

MAP2K6

A gene on chromosome 17q24.3 that encodes a dual-specificity protein kinase that is an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, MAP2K6 catalyses the phosphorylation of threonine and tyrosine residues in the MAP kinases MAPK11, MAPK12, MAPK13 and MAPK14, and it plays a key role in cellular responses to cytokines and cellular stress. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress; MAP2K6/MKK6 mediates apoptotic cell death in thymocytes, regulates melanocyte dendricity by modulating modulation Rho family GTPases, and is the major MAPK11 activator in response to TNF.
References in periodicals archive ?
Cohen, "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases," The EMBO Journal, vol.