SIX3

SIX3

A gene on chromosome 2p21 that encodes a member of the sine oculis homeobox (SIX) transcription factor family which plays a role in eye development.

Molecular pathology
SIX3 mutations are associated with holoprosencephaly type 2.
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As steward of our long-standing and highly-successful acquisition program, Ken oversaw the acquisitions of Six3 Systems, NSS and LGS Innovations, as well as others, which increased our ability to pursue specialized, high-value, and high growth markets.
This lncRNA was shown to activate the targets of the retinal development involving the Six3 transcription factor (29).
Nonsyndromic holoprosencephaly can be related with heterozygous mutation of the SHH, ZIC2, SIX3, and TIGF1 genes; however, in rare cases, a possible link to the patched1 (PTCH1) gene localized to the ninth chromosome and that suppresses the SHH pathway has also been reported (7).
Immunocytochemistry showed that these cells expressed the corresponding markers, such as SOX1, PAX6, OTX2, LHX2, and SIX3 (Figures 2(d)-2(h)).
DARPA awarded nine phase-one contracts to industry including: Helios Remote Sensing Systems, Kitware, Leidos, Lockheed Martin, Raytheon, Scientific Systems Company Inc., Six3 Systems Inc., SoarTech and SRI International.
Meet the NSA Spinouts Startup companies based on technology from the National Security Agency Integrata Security Baltimore $540,000 raised KeyW Hanover, MD Publicly traded Six3 Systems McLean, VA Acquired Sqrrl Cambridge, MA $7.2 million raised Fixmo Toronto $41 million raised Integrata Security Wireless monitoring systems KeyW Geospatial intelligence Six3 Systems Surveillance solutions Sqrrl Enterprise databases Fixmo Mobile security
US information services provider CACI International Inc (NYSE:CACI) said it had completed the purchase of domestic national security and defence intelligence services provider Six3 Systems Inc from private equity firm GTCR LLC for USD820m (EUR607.2m).
Marvin Whitfield, forensics expert and team leader for the Six3 Systems Battlefield Forensics Mobile Training Course, said the training makes military members more valuable assets while downrange.
Pax6 influences ocular surface development both directly by controlling the expression of different genes that play critical roles in the ocular surface and indirectly by controlling many other transcription factors including Six3, c-Maf, MafA/L-Maf, Prox1, Sox2, and Foxe3 that play important roles in the ocular surface (Figure 4) [3, 79, 99-105].
https://six3.tv/ The London-based company Six3, has launched a new video-sharing app by the same name that will enable users to send short video messages as easily as sending a text.
The purpose of the training as described by Frederick King, an instructor and senior analyst with Six3 Systems and the USAMPS, "is to take the insurgents off the battlefield."
Four genes for holoprosencephaly are known: SHH (7q36), ZIC2 (13q32), SIX3 (2p21), and TGIF mapped in the distal most part of the short arm of chromosome 18 (18p11.3) (4).