SIX1

SIX1

A gene on chromosome 14q23.1 that encodes a homeobox protein similar to the Drosophila “sine oculis” gene product and thought to be involved in limb development.

Molecular pathology
SIX1 mutations are linked to autosomal dominant deafness type 23 and branchiootic syndrome type 3.
References in periodicals archive ?
The transcriptional coactivator Eya1 and the homeobox gene Six1 are believed to participate in the early differentiation of hair cells and neurons (10), which are in turn regulated by Foxil (11).
Expression and significance of Six1 and Ezrin in cervical cancer tissue.
Similar observations were seen in overexpression of MyoD in P19 embryonal carcinoma stem cells, which can induce paraxial mesodermal genes including Meox1, Pax3, Pax7, Six1, and Eya2 followed by muscle-specific genes.
PAX3 and SIX1 expression by immunohistochemistry (43) and gene-expression analysis (44) has recently been identified in borderline and malignant PTs and correlates with a poor clinical outcome.
P53 expression level is decreased by Sineoculishomeobox homolog 1 (Six1) in response to DNA damage in a proteasome independent manner [15].
Since the loss of E-cadherin expression is considered a crucial event in EMT, EMT-TFs have been classified based on their ability to repress E-cadherin directly (SNAIL, SLUG, ZEB1, ZEB2, etc.) or indirectly (TWIST1, TWIST2, E2.2 SIX1, FOXC2, etc.) [46].
There was the further "discovery" of single digits 6 and 7 on six1 folios (including the number 6 on V&A 1508-1883 I.S.), which were proposed as "volume numbers" (Seyller 1993, p.
Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32.
Tokyo, Nov 20, 2014 - (JCN Newswire) - Toyota Motor Corporation will hold a series of six1 classical-music concerts in cities throughout Japan between April 2 and April 12, 2015.
Early in human development, we depend on a transcription factor called SIX1 to create this weed-like growth and nimble movement.
Estos genes incluyen factores de transcripcion como Six1. que se expresa inicialmente en toda el area preplacodal: Pax8, expresado en el dominio posterior del sector preplacodal, los cuales son precursores de la placoda otica.
Blackberries, one dish of six1 L Wildman, 2 S Smith.