SIRT7

SIRT7

A gene on chromosome 17q25 that encodes an NAD-dependent protein deacetylase, which is required to restore the transcription of ribosomal RNA at the exit from mitosis. It facilitates association of RNA polymerase I with the rDNA promoter and coding regions, and stimulates transcription at the RNA polymerase I complex
References in periodicals archive ?
SIRT1, SIRT6, and SIRT7 are found in the nucleus; SIRT3, SIRT4, and SIRT5 are found in the mitochondria; and SIRT2 is primarily found in the cytoplasm (21).
For men, DNAJB5, RAC3, EAPP, HDLBP, PRG2, PER1, PIK31, and SLA2 were selected for validation, whereas for women the gene list for validation included AKAP6, LIMK1, SIRT7, ARHPGAP4, ATG16L2, TPM3, 5-HT1B, and PYGO2.
5]-exposure analysis for women identified PYGO2, SIRT7, and ATG16L2 as significantly associated with particulate matter exposure.
sup][12] SIRT7 is the least studied Sirtuin family member, but until now it has been investigated that SIRT7 as deacetylase can target substates p53, H3K18, PAF53 and so on.
SIRT7 is primarily located in nucleus (especially in nucleolar regions).
There are seven sirtuin enzymes in mammals, identified by number: SIRT1 through SIRT7.
In mammals, they make up a family of seven members known as SIRT1 to SIRT7 (Haigis and Guarente, 2006).
SIRT7, Sirtuin (silent mating type information regulation 2 homolog) 7 (S.
There are seven sirtuins in mammals, numbered SIRT1 to SIRT7.
Guarente, "Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription," Genes and Development, vol.
7) Complicating the question of how sirtuins affect aging is the fact that mammals have at least seven different sirtuins, designated SIRT1 - SIRT7.
SIRT7 has metastasis-promoting effects, upregulating the motility and invasiveness of cancer cells of either epithelial or mesenchymal origin in vitro and increasing their metastatic potential in vivo.