SIRT5

SIRT5

A gene on chromosome 6p23 that encodes an NAD-dependent enzyme that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and helps regulate blood ammonia levels during prolonged fasting by desuccinylating CPS1, thereby increasing its activity in response to elevated NAD levels.
References in periodicals archive ?
SIRT1, SIRT6, and SIRT7 are found in the nucleus; SIRT3, SIRT4, and SIRT5 are found in the mitochondria; and SIRT2 is primarily found in the cytoplasm (21).
SIRT3, SIRT4, and SIRT5 localize to the mitochondria, where approximately 90% ofROS are produced in mitochondria [126].
sup][10] Recently, it has been found that SIRT5 displays demalonylase and desuccinylase activity by removing malonyl or succinyl moiety from target protein, such as carbamoyl phosphate synthase 1.
DeCarli, "Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function," Biochemical and Biophysical Research Communications, vol.