SIRT4


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SIRT4

A gene on chromosome 12q24.31 that encodes an NAD-dependent protein ADP-ribosyl transferase that catalyses the transfer of ADP-ribosyl groups onto target proteins (e.g., mitochondrial GLUD1), inhibiting its enzyme activity. SIRT4 interacts with GLUD1, IDE and SLC25A5, is widely expressed, especially in vascular smooth muscle, striated muscle and in beta-cells in pancreas islets; it downregulates insulin secretion.
References in periodicals archive ?
SIRT4, unlike other sirtuins, mostly functions as a histone ADP-ribosyltransferase but does not have NAD-dependent deacetylase activity [52].
Emerging Evidence concerning the Role of Sirtuins in Sepsis
Haigis et al., "SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic [beta] cells," Cell, vol.
Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals
Shen, "MicroRNA-497 inhibits cardiac hypertrophy by targeting Sirt4," PLoS ONE, vol.
MicroRNA as a Therapeutic Target in Cardiac Remodeling
As discussed above, other Sirtuins, especially, SIRT4 is also a mitochondrial deacetylase as SIRT3 and functions as tumor suppressor via modulating glutamine metabolism.
Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively
SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.
Mitochondria: overlooking these small organelles can have huge clinical consequences in treating virtually every disease
SIRT4, a less studied mitochondrial sirtuin, is an integral part of the metabolic response to genotoxic stress.
Marcia Haigis to Keynote Present at 5th Cancer Targets & Therapeutics - July 7-8, 2014, in Boston
SIRT4, a member of sirtuin family exclusively localized in mitochondria, plays an important role in mitochondrial metabolism [118].
MicroRNA Regulation of Oxidative Stress-Induced Cellular Senescence
The Sirt family includes several members localized in different subcellular compartments: the nuclei (Sirtl, Sirt2, Sirt6, and Sirt7), cytoplasms (Sirtl and Sirt2), and mitochondria (Sirt3, Sirt4, and Sirt5) [9, 10].
An Extract from the Plant Deschampsia antarctica Protects Fibroblasts from Senescence Induced by Hydrogen Peroxide
In addition SIRT4, SIRT6, and SIRT7 exhibit monoadenosine diphosphate(ADP-) ribosyltransferase activity.
Sirtuins Expression and Their Role in Retinal Diseases
An et al., "SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity," European Heart Journal, vol.
A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling
It is acknowledged that the silent information regulator 2 (SIR2) complex is composed of 4 groups, including group I with sirtuin 1 (Sirtl), 2, and 3; group II with Sirt4; group III with Sirt5; and group IV with Sirt6 and 7 [8].
Sirtl Protects Endothelial Cells against LPS-Induced Barrier Dysfunction
Despite conserved deacetylase domains, mitochondrial sirtuin 4 (Sirt4) is the most efficient lipoamidase among mitochondrial sirtuins.
Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association
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