SIRT4


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SIRT4

A gene on chromosome 12q24.31 that encodes an NAD-dependent protein ADP-ribosyl transferase that catalyses the transfer of ADP-ribosyl groups onto target proteins (e.g., mitochondrial GLUD1), inhibiting its enzyme activity. SIRT4 interacts with GLUD1, IDE and SLC25A5, is widely expressed, especially in vascular smooth muscle, striated muscle and in beta-cells in pancreas islets; it downregulates insulin secretion.
References in periodicals archive ?
SIRT4, unlike other sirtuins, mostly functions as a histone ADP-ribosyltransferase but does not have NAD-dependent deacetylase activity [52].
Haigis et al., "SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic [beta] cells," Cell, vol.
Shen, "MicroRNA-497 inhibits cardiac hypertrophy by targeting Sirt4," PLoS ONE, vol.
As discussed above, other Sirtuins, especially, SIRT4 is also a mitochondrial deacetylase as SIRT3 and functions as tumor suppressor via modulating glutamine metabolism.
SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.
SIRT4, a less studied mitochondrial sirtuin, is an integral part of the metabolic response to genotoxic stress.
SIRT4, a member of sirtuin family exclusively localized in mitochondria, plays an important role in mitochondrial metabolism [118].
The Sirt family includes several members localized in different subcellular compartments: the nuclei (Sirtl, Sirt2, Sirt6, and Sirt7), cytoplasms (Sirtl and Sirt2), and mitochondria (Sirt3, Sirt4, and Sirt5) [9, 10].
In addition SIRT4, SIRT6, and SIRT7 exhibit monoadenosine diphosphate(ADP-) ribosyltransferase activity.
An et al., "SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity," European Heart Journal, vol.
It is acknowledged that the silent information regulator 2 (SIR2) complex is composed of 4 groups, including group I with sirtuin 1 (Sirtl), 2, and 3; group II with Sirt4; group III with Sirt5; and group IV with Sirt6 and 7 [8].
Despite conserved deacetylase domains, mitochondrial sirtuin 4 (Sirt4) is the most efficient lipoamidase among mitochondrial sirtuins.