SIRT3

SIRT3

A gene on chromosome 11p15.5 that encodes a widely expressed NAD-dependent enzyme that deacetylates key lysine residues, activating mitochondrial target proteins (e.g., ACSS1, IDH2 and GDH), thereby playing a role in cellular energy metabolism by regulating tissue-specific ATP levels.
References in periodicals archive ?
The mitochondria contain three of the seven mammalian sirtuins, including SIRT3 and SIRT4.
Mitochondria: overlooking these small organelles can have huge clinical consequences in treating virtually every disease
The SIRT3 gene encodes a protein also called SIRT3.
Could Feast-And-Famine Diet Help Extend Life?
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle.
Major advance in slowing aging
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Mitochondria, energetics, epigenetics, and cellular responses to stress
It was discovered that SIRT3, a mitochondrial deacetylase, represses cellular glycolysis through the regulation of HIF1alpha, a transcription factor that increases gene expression of glycolytic targets.
Marcia Haigis to Keynote Present at 5th Cancer Targets & Therapeutics - July 7-8, 2014, in Boston
Ethanol-induced suppression of SIRT3 and the concomitant increase of another acetylation pathway (i.
Alcohol metabolism and epigenetics changes
The biologists found that SIRT3, one among a class of proteins known as sirtuins, plays an important role in helping aged blood stem cells cope with stress.
Longevity gene may lead to 'molecular fountain of youth'
A study by Sirtris Scientific Advisory Board members and Harvard University scientists, published in the journal Cell in September 2007, showed for the first time that activation of SIRT3 and SIRT4 protects against cell damage.
Sirtris Completes Exclusive License to Harvard's SIRT3-Based Intellectual Property
9,17,18) Sirtuins, specifically SIRT1 and SIRT3, are intimately related to longevity through their control of gene expression and require NAD+ for their activity.
"Next generation" vitamin provides hope to aging societies worldwide
2007; Feng and Forgac 1992); and HNE adduct formation at Cys280 inhibits mitochondrial SIRT3 (SIRT3) activity (Fritz et al.
Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry
Previous studies indicated that two other members of the sirtuin family - SIRT1 and SIRT3 - have tumour suppressor functions.
New protein behind aging, cancer identified
Such statements include, but are not limited to, the potential therapeutic effects of SIRT1 activators for diseases of aging, such as Type 2 Diabetes, cancer, and other disorders; the potential effects of SIRT3 activators for metabolic diseases; the progress and potential results of pre-clinical and clinical studies of SRT501 and novel chemical entities; the initiation of additional clinical trials to test the potential therapeutic effects of SIRT1 activators; the possibility of a strategic partnership within the next 12-18 months; and the potential of sirtuin activators to receive regulatory approval.
Sirtris Pharmaceuticals Reports Fourth Quarter and 2007 Financial Results; Significant Progress Achieved
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