SIRT3

SIRT3

A gene on chromosome 11p15.5 that encodes a widely expressed NAD-dependent enzyme that deacetylates key lysine residues, activating mitochondrial target proteins (e.g., ACSS1, IDH2 and GDH), thereby playing a role in cellular energy metabolism by regulating tissue-specific ATP levels.
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We found that in response to fasting every other day, the cells made more copies of a gene called SIRT3, which is part of a pathway that works to prevent free radical production and (http://www.
This study aimed to evaluate SIRT2 and SIRT3 mRNA expressions in patients with RA.
SIRT3 may protect people against Alzheimer's disease by strengthening the batteries inside their brain cells.
sup][17] SIRT3 is involved in dealing with oxidative stress for cells at under CR.
The mitochondria contain three of the seven mammalian sirtuins, including SIRT3 and SIRT4.
The SIRT3 gene encodes a protein also called SIRT3.
It was discovered that SIRT3, a mitochondrial deacetylase, represses cellular glycolysis through the regulation of HIF1alpha, a transcription factor that increases gene expression of glycolytic targets.
Ethanol-induced suppression of SIRT3 and the concomitant increase of another acetylation pathway (i.
The biologists found that SIRT3, one among a class of proteins known as sirtuins, plays an important role in helping aged blood stem cells cope with stress.
Notably, SIRT3 is found in a cell's mitochondria, a cell compartment that helps control growth and death, and previous studies have shown that the SIRT3 gene is activated during calorie restriction, which has been shown to extend lifespan in various species.
A study by Sirtris Scientific Advisory Board members and Harvard University scientists, published in the journal Cell in September 2007, showed for the first time that activation of SIRT3 and SIRT4 protects against cell damage.
SIRT3, a mammalian SIR2 homolog localized in the mitochondria, regulates several aspects of mitochondrial function, including metabolism, energy homeostasis, and modulation of the response to oxidative stress [4].