SIRT3

SIRT3

A gene on chromosome 11p15.5 that encodes a widely expressed NAD-dependent enzyme that deacetylates key lysine residues, activating mitochondrial target proteins (e.g., ACSS1, IDH2 and GDH), thereby playing a role in cellular energy metabolism by regulating tissue-specific ATP levels.
References in periodicals archive ?
SIRT3 has become a novel target pursued substantially for its involvement in regulation of aging and agerelated diseases, possibly due to its well-known association with exceptionally long lifespan in humans as well as its mitochondrial localization (5).
Moderate-intensity exercise allows enhanced protection against oxidative stress-induced cardiac dysfunction in spontaneously hypertensive rats
Sodium fluoride induces nephrotoxicity via oxidative stress-regulated mitochondrial SIRT3 signaling pathway.
ATTENUATION OF SODIUM FLUORIDE INDUCED NEPHROTOXICITY BY FRESH ORANGE JUICE IN MICE
Tenders are invited for Supply of Sirt3 activity assay kit flurometric ab156067
Supply Of Sirt3 Activity Assay Kit Flurometric Ab156067
[5.] Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP: Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
Engineered Biomaterial Surfaces for Neonatal Murine Cardiomyocyte Culture Toward Understanding Cardiac Hypertrophy
D'Cunha, "Minnelide/Triptolide impairs mitochondrial function by regulating SIRT3 in P53-dependent manner in non-small cell lung cancer," PLoS One, vol.
Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy
It is 200-500fold more selective for SIRT1 than for SIRT2, SIRT3, or SIRT6, has a half-life of 2h, and is active in <100 nM concentrations [42].
Sirtuinl Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice
Meng et al., "Acetylation-dependent regulation of mitochondrial ALDH2 activation by SIRT3 mediates acute ethanol-induced eNOS activation," FEBS Letters, vol.
Effect of Lycosome-Formulated Phosphatidylcholine on Parameters of Biological Oxidation after Single Intake of Moderate Amount of Alcohol
Notably, the distribution of some isoforms (e.g., SIRT1, SIRT2, SIRT3, and SIRT5) is varied due to their specific activity [2].
Emerging Evidence concerning the Role of Sirtuins in Sepsis
PGC-1[alpha] targets SIRT3, a mitochondrial deacetylase, which promotes mitochondrial biogenesis, suppression of ROS [46], and mitochondrial FA oxidation [47].
Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress
Keffler et al., "SIRT3 deacetylates ceramide synthases: Implications for mitochondrial dysfunction and brain injury," The Journal of Biological Chemistry, vol.
Ceramide and Ischemia/Reperfusion Injury
Three key enzymes involved in the sensing of these perturbations and the subsequent induction of signal transduction are AMP-activated protein kinase (AMPK) and silent mating type information regulation 2 homologues 1 and 3 (SIRT1 and SIRT3).
Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health
Shi et al., "Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3," Molecular and cellular biology, vol.
Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion
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