SIRT3

SIRT3

A gene on chromosome 11p15.5 that encodes a widely expressed NAD-dependent enzyme that deacetylates key lysine residues, activating mitochondrial target proteins (e.g., ACSS1, IDH2 and GDH), thereby playing a role in cellular energy metabolism by regulating tissue-specific ATP levels.
References in periodicals archive ?
We found that in response to fasting every other day, the cells made more copies of a gene called SIRT3, which is part of a pathway that works to prevent free radical production and (http://www.
How To Relieve Stress And Lose Weight At The Same Time
This study aimed to evaluate SIRT2 and SIRT3 mRNA expressions in patients with RA.
Changes in sirtuin 2 and sirtuin 3 mRNA expressions in rheumatoid arthritis
SIRT3 may protect people against Alzheimer's disease by strengthening the batteries inside their brain cells.
5 ways scientists could supercharge long-term care insurance
sup][17] SIRT3 is involved in dealing with oxidative stress for cells at under CR.
Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively
The mitochondria contain three of the seven mammalian sirtuins, including SIRT3 and SIRT4.
Mitochondria: overlooking these small organelles can have huge clinical consequences in treating virtually every disease
The SIRT3 gene encodes a protein also called SIRT3.
Could Feast-And-Famine Diet Help Extend Life?
It was discovered that SIRT3, a mitochondrial deacetylase, represses cellular glycolysis through the regulation of HIF1alpha, a transcription factor that increases gene expression of glycolytic targets.
Marcia Haigis to Keynote Present at 5th Cancer Targets & Therapeutics - July 7-8, 2014, in Boston
Ethanol-induced suppression of SIRT3 and the concomitant increase of another acetylation pathway (i.
Alcohol metabolism and epigenetics changes
The biologists found that SIRT3, one among a class of proteins known as sirtuins, plays an important role in helping aged blood stem cells cope with stress.
Longevity gene may lead to "molecular fountain of youth"
Notably, SIRT3 is found in a cell's mitochondria, a cell compartment that helps control growth and death, and previous studies have shown that the SIRT3 gene is activated during calorie restriction, which has been shown to extend lifespan in various species.
Longevity gene may lead to 'molecular fountain of youth'
A study by Sirtris Scientific Advisory Board members and Harvard University scientists, published in the journal Cell in September 2007, showed for the first time that activation of SIRT3 and SIRT4 protects against cell damage.
Sirtris Completes Exclusive License to Harvard's SIRT3-Based Intellectual Property
SIRT3, a mammalian SIR2 homolog localized in the mitochondria, regulates several aspects of mitochondrial function, including metabolism, energy homeostasis, and modulation of the response to oxidative stress [4].
Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation
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