Deacetylation of FOXO3 by Sirt1 or
SIRT2 leads to Skp2-mediated FOX03 ubiquitination and degradation.
SUV4- (PHF8) 20H2) Fosforilacion Serina/ Fosforilasa de H3S10, H3T3 treonina proteina quinasa (Haspin) Descompactacion Acetilacion de HAT (TIP60) Deacetilasa lismas en H3 y (
Sirt2) H4 Trimetilacion HMT (Set1) Desmetilasa de H3K4 (Jhd2) Fuente: adaptado de (54), (55) y (58).
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.
Seven sirtuins exist with specific locations in the cell: Sirt1,6 and 7 are in the nucleus,
Sirt2 in the cytosol, and Sirts3, 4, and 5 in the mitochondria (33).
Aging-related rotenone-induced neurochemical and behavioral deficits: role of
SIRT2 and redox imbalance, and neuroprotection by AK-l.
Now, a team of Japanese researchers has identified a sirtuin enzyme (
Sirt2) as a key player in regulating hepatic glucokinase through modifying GKRP, suggesting that this mechanism offers a potential therapeutic target for type 2 diabetes.
SIRT1 and SIRT6 are mainly located in the nucleus, whereas
SIRT2 is mainly present in the cytoplasm.
CDK9's role in promoting genome integrity is regulated at least in part through deacetylation by the
SIRT2 sirtuin deacetylase and breast tumor suppressor protein, which promotes its kinase activity [11] and in turn phosphorylates UBE2A and directs H2Bub1 and PCNA ubiquitinylation [12].
Zhai et al., "MicroRNA-7 inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax and
Sirt2," American Journal of Translational Research, vol.
Dominguez-Andres et al., "Chronic stress and antidepressant induced changes in Hdac5 and
Sirt2 affect synaptic plasticity," European Neuropsychopharmacology, vol.
It is 200-500fold more selective for SIRT1 than for
SIRT2, SIRT3, or SIRT6, has a half-life of 2h, and is active in <100 nM concentrations [42].
This study aimed to evaluate
SIRT2 and SIRT3 mRNA expressions in patients with RA.