Deacetylation of FOXO3 by Sirt1 or SIRT2
leads to Skp2-mediated FOX03 ubiquitination and degradation.
SUV4- (PHF8) 20H2) Fosforilacion Serina/ Fosforilasa de H3S10, H3T3 treonina proteina quinasa (Haspin) Descompactacion Acetilacion de HAT (TIP60) Deacetilasa lismas en H3 y (Sirt2
) H4 Trimetilacion HMT (Set1) Desmetilasa de H3K4 (Jhd2) Fuente: adaptado de (54), (55) y (58).
induces the checkpoint kinase BubR1 to increase lifespan.
Seven sirtuins exist with specific locations in the cell: Sirt1,6 and 7 are in the nucleus, Sirt2
in the cytosol, and Sirts3, 4, and 5 in the mitochondria (33).
Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2
and redox imbalance, and neuroprotection by AK-l.
Now, a team of Japanese researchers has identified a sirtuin enzyme (Sirt2
) as a key player in regulating hepatic glucokinase through modifying GKRP, suggesting that this mechanism offers a potential therapeutic target for type 2 diabetes.
SIRT1 and SIRT6 are mainly located in the nucleus, whereas SIRT2
is mainly present in the cytoplasm.
CDK9's role in promoting genome integrity is regulated at least in part through deacetylation by the SIRT2
sirtuin deacetylase and breast tumor suppressor protein, which promotes its kinase activity  and in turn phosphorylates UBE2A and directs H2Bub1 and PCNA ubiquitinylation .
Zhai et al., "MicroRNA-7 inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax and Sirt2
," American Journal of Translational Research, vol.
Dominguez-Andres et al., "Chronic stress and antidepressant induced changes in Hdac5 and Sirt2
affect synaptic plasticity," European Neuropsychopharmacology, vol.
It is 200-500fold more selective for SIRT1 than for SIRT2
, SIRT3, or SIRT6, has a half-life of 2h, and is active in <100 nM concentrations .
This study aimed to evaluate SIRT2
and SIRT3 mRNA expressions in patients with RA.