SIRT2

SIRT2

A gene on chromosome 19q13 that encodes a widely expressed NAD-dependent enzyme that deacetylates Lys-40 of alpha-tubulin and is involved in controlling mitotic exit in the cell cycle, possibly by cytoskeletal regulation.
References in periodicals archive ?
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.
This study aimed to evaluate SIRT2 and SIRT3 mRNA expressions in patients with RA.
SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-?
Third, using a candidate-gene approach based on a literature search for air pollution associated genes we investigated separately a set of 739 CpGs in 38 antioxidant and inflammatory genes (TGFB1, ARG1, ARG2, GSTM1, GSTP1, NQO1, SOD2, GPX1, HMOX-1, CAT, GSTT1, EPHX1, NOS2, TNF, NFE2L2, GSS, GPX7, GPX2, GSTZ1, ALB, SRXN1, NOX5, ALOX12, NCF2, AOX1, MPV17, SIRT2, MBL2, OXSR1, OXR1, NUDT1, DUOX2, EPX, PXDNL, PXDN, MPO, LPO, TPO) (Carlsten and Melen 2012; Chen et al.
SIRT2, a NAD-dependent histone deacetylase, was also found to be involved in LPS-induced ROS generation in macrophages; deletion of SIRT2 inhibited NF-[kappa]B p65 nuclear translocation and M1 related gene expressions [106].
Many studies have shown that an extra copy of SIRT2 genes improved life expectancy by 50 percent, while its deletion lowered longevity.
The new study by investigators at Vanderbilt-Ingram Cancer Centre and the National Institutes of Health (NIH) identifies the protein SIRT2 as a tumour suppressor linked to gender-specific tumour development in mice.
Laboratory tests showed that blocking the action of a brain protein called SIRT2 may help prevent damage to neurons.
SIRT2 is prevalently in the cytoplasm and has been found to accumulate in neurons, while other SIRTs localize primarilyin the mitochondria [97].
sup][18] Latest SIRT2 has been found a key modulator of aging, and it extends lifespan in BubR1 mice model.
The seven known sirtuins in mammals are identified by number: SIRT1, SIRT2 .
SIRT2 is a cytoplasmic sirtuin that deacetylates and therefore destabilizes [alpha]-tubulin [149].