SIRPA

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SIRPA

A gene on chromosome 20p13 that encodes a ubiquitous immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment, and may play a key role in intracellular signalling during synaptogenesis and in synaptic function. It downregulates receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors and insulin; it also downregulates phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. It is highly expressed in the brain.
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This suggestion first came from Neena Chappell and Peter Stephenson, at an SIRP research meeting and was subsequently discussed with the interviewers, who agreed that, based on their experience, it was perhaps an important factor to consider.
This resulted in the development of the SIRP model as an alternative to standard approaches to meet ESDC's needs and specific circumstances (Figure 2).
The conceptual basis for SIRP rests on common approaches to knowledge transfer, the spheres of influence approach, in order to highlight the importance of the transfer of policy research knowledge.
The SIRP model speaks to the linkages between policy researchers and research users illustrated through successive layers of influence.
It is worth noting that, like the payback framework, SIRP aligns multiple spheres with multiple impact categories.
To this end, we compared a prevalent model of research impact assessment and proposed an alternative model for social science research in government in the SIRP.
Though we propose SIRP as a better alternative, there are undoubtedly advantages for government departments to shorten implementation through the adaptation of an existing PM approach.
L'equipe peut ainsi tirer profit d'un des atouts du SIRP : la capacite de deployer une equipe de soutien multidisciplinaire et de creer des synergies professionnelles pour servir le Parlement et ses comites.
SIRP will improve productivity and climate resilient crop production under both rainfed and irrigated conditions, through diversification of crops and increased adoption of improved varieties, combined with climate-smart agricultural practices and most importantly, enhanced access to markets.
19 hit 6%, according to SIRPs analysis of check stand scan data from major food and drug stores in the United States.
SIRPs priciest category measured, $20-plus, grew an amazing 37% over the same four-week period in 2011, presumably because people splurged on the fastest growing high-priced varietals-Pinot Noir and Sauvignon Blanc--to accompany their Easter ham.