SIK1

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SIK1

A gene on chromosome 21q22.3 that encodes a serine/threonine-protein kinase involved in a plethora of cellular processes, including cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation, and tumour suppression. Once activated by by CaMK1, SIK1 regulates cognate proteins by phosphorylating them: it phosphorylates p53/TP53 in response to loss of adhesion thereby suppressing metastasis; it phosphorylates the PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of the sodium/potassium-transporting ATPase, ATP1A1, and subsequent increase of ATP1A1’s activity; and it phosphorylates muscle cells, inhibiting class-II histone deacetylases HDAC4 and HDAC5, thus promoting expression of MEF2 target genes in myocytes.

SIK1 is required during cardiomyogenesis, and regulates the exit of cardiomyoblasts from the cell cycle by downregulating CDKN1C/p57Kip2. SIK1 regulates hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators TORC1/CRTC1 and TORC2/CRTC2, inhibiting CREB activity; it also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1.

Molecular pathology
Defects in SIK1 are associated with breast and other cancers, and generally carry a poor prognosis.
References in periodicals archive ?
Sik Kim hailed the security arrangements for the tournament and said that in Islamabad there is no security related issue.
Ancak literaturde kunt ve indirekt travmalar, kesici ve direkt travmalardan daha sik karsimiza cikmaktadir.
This year it aims to increase visitor numbers from the GCC by "at least 50 per cent" and from the UAE by "more than 100 per cent," Sik Yuen said.
Yonhap said the replacement of Kim Kyok Sik with a relatively "young" and unknown field commander after only eight months in the job may signal a shift in North Korea's confrontational policies.
Retail drugstore China Nepstar Chain Drugstore Ltd (NYSE:NPD) revealed on Thursday the departure of Gary Siu Kwan Sik as its independent director with immediate effect.
March 12 2012 (TUR) -- Turkish deputy premier said on Monday that he was pleased with release of journalists; Nedim Sener, Ahmet Sik, Sait Cakir and Coskun Musluk within the scope of the case into Odatv news portal.
Hana Financial Group (086790.SE) (OP: HNFGF), South Korea's second largest financial holding firm by assets, has said that it has named Choe Heung Sik as the new president for the group, and Kim Jong-jun as chief executive for its banking unit, Hana Bank.