SIADH

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syndrome

[sin´drōm]

a combination of symptoms resulting from a single cause or so commonly occurring together as to constitute a distinct clinical picture. For specific syndromes, see under the name, such as adrenogenital syndrome or reye's syndrome. See also disease and sickness.

syndrome of crocodile tears spontaneous lacrimation occurring parallel with the normal salivation of eating. It follows facial paralysis and seems to be due to straying of the regenerating nerve fibers, some of those destined for the salivary glands going to the lacrimal glands.

syndrome of inappropriate antidiuretic hormone (SIADH) a syndrome in which secretion of vasopressin (antidiuretic hormone) is not inhibited by hypotonicity of extracellular fluid and hyponatremia is produced. It occurs in conjunction with oat cell carcinoma of the lung and certain other malignant tumors and is caused by production of vasopressin by the tumor. See also ectopic hormones.

SIADH

Abbreviation for syndrome of inappropriate secretion of antidiuretic hormone.

SIADH

syndrome of inappropriate antidiuretic hormone.

SIADH

abbreviation for syndrome of inappropriate antidiuretic hormone secretion.

SIADH

Syndrome of inappropriate antidiuretic hormone secretion. A condition characterised by increased vasopressin/ADH secretion (despite low plasma osmolarity), water retention and dilutional hyponatraemia.

Aetiology
Addison’s disease, ACTH deficiency, AIDS, hypopituitarism, paraneoplastic hormone production (small cell carcinoma of lung, bronchogenic, pancreas, uterine, bladder or prostate), lymphoproliferative disorders, mesothelioma, thymoma, CNS disease (trauma, infection, chromophobe adenoma), metastases, lung disease (TB, pneumonia, PEEP ventilation), porphyria, drugs (e.g., chlorpropamide, vincristine, etc.).

Lab
Hypervolemia, hypouricaemia, decreased creatinine, hyponatraemia, natriuresis (urinary sodium > 20 mEq/L with decreased BUN), no symptoms of volume depletion, decreased maximum urinary dilution, increased ADH, normal renal and adrenal function.

Management
Corticosteroids to suppress ADH secretion.

SIADH

Syndrome of inappropriate antidiuretic hormone secretion, dilutional hyponatremia A complex characterized by ↑ vasopressin–ADH secretion despite low plasma osmolarity, water retention, dilutional hyponatremia Etiology Addison's disease, ACTH deficiency, AIDS, hypopituitarism, ectopic hormone production in CA–small cell, bronchogenic, pancreas, uterine, bladder, prostate, lymphoproliferative disorders, mesothelioma, thymoma, CNS disease–trauma, infection, chromophobe adenoma, metastases, lung disease–TB, pneumonia, PEEP ventilation, porphyria, drugs–eg, chlorpropamide, vincristine, etc Lab Hypervolemia, hypouricemia, ↓ creatinine, hyponatremia, natriuresis–urinary sodium > 20 mEq/L with ↓ BUN, no Sx of volume depletion, ↓ maximum urinary dilution, ↑ ADH, normal renal and adrenal function Management Corticosteroids to suppress ADH secretion

SIADH

Abbreviation for syndrome of inappropriate antidiuretic hormone secretion.

SIADH

Abbrev. for Syndrome of Inappropriate Antidiuretic Hormone. This is a condition in which excessive production of ADH (also known as vasopressin) by the PITUITARY GLAND results in water retention and low levels of sodium. The syndrome occurs in various serious diseases, especially cancer.

SIADH

Abbreviation for syndrome of inappropriate secretion of antidiuretic hormone.

SIADH

syndrome of inappropriate secretion of antidiuretic hormone.

References in periodicals archive ?

CSW has similar laboratory findings to SIADH but is less commonly seen after TS pituitary surgery.

Managing the patient with transsphenoidal pituitary tumor resection

The main differential factor in CSWS and SIADH is extracellular volume status (1).

Water and salt metabolism disorders following transsphenoidal pituitary surgery/Transsfenoidal hipofiz cerrahisi sonrasi gorulen sivi elektrolit bozukluklari

Additionally, urine [Na+] in the two fatal cases was greater than 30 mEq/L, which natriuretic effect is consistent with the decrease in free water clearance under conditions of SIADH rather than representing renal salt wasting.

Treatment of EAH-induced encephalopathy with hypertonic (3%) saline: new paradigm, new therapy

28,29) Dysfunctions in AQP2 and its regulation system are associated with NDI and SIADH, while elevated AQP2 levels are associated with conditions such as CHF and liver cirrhosis and quantitation of AQP2 levels may help assess the condition.

CLS meets the aquaporin family: clinical cases involving aquaporin systems

7] Transient (acute) forms of SIADH may be drug-induced or appear in the postoperative patient, usually producing clinical signs and symptoms for 3-5 days after surgery.

ADH-associated pathologies

1%) were diagnosed to have SIADH (malignancy n=2, chest infection n=2, CVA n=1) one of these patients had also underlying hypovolaemia (Table-3).

Hyponatraemia: Epidemiology and aetiology in a tertiary care centre in Pakistan

6-8) SIADH occurs in about one-third of children hospitalised for pneumonia and is associated with a more severe disease and a poorer outcome.

Correlation of hyponatraemia in children with lower respiratory tract infection--an institutional observational study

In our case, we identified at least 4 possible causes of SIADH and hyponatremia:

Severe hyponatremia due to levofloxacin treatment for Pseudomonas aeruginosa community-acquired pneumonia in a patient with oropharyngeal cancer

While the workup shows hypernatremia, serum hypo-osmolality, urine osmolality >100 mosm/kg (serum osmolality is lower than urine osmolality), decrease urine output, normal urine sodium concentration and potassium and acid base concentration which are going with SIADH criteria.

Confusion in a patient with mycoplasma pneumonia lowers threshold to lumbar puncture despite hyponatremia

SIADH is a relatively rare syndrome that has been associated with neurosurgery, hemorrhagic stroke, brain tumors, central nervous system infections, and respiratory infection (5).

A case with insulinoma experiencing syndrome of inappropriate secretion of ADH/Insulinoma ve eslik eden uygunsuz ADH sendromu olan olgu

He was hyponatremic as a result of SIADH (syndrome of inappropriate antidiuretic hormone secretion) and had mild pulmonary edema.

Bilateral cerebellopontine angle metastatic melanoma: a case report

The pathophysiology of SIADH as the proximate cause of EAH accounts for otherwise puzzling clinical observations such as cases occurring after only moderate fluid intake or presenting hours after races.