SHROOM4

SHROOM4

A gene on chromosome Xp11.22 that encodes a protein which may regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II; it thus plays a key role in development.

Molecular pathology
Defects of SHROOM4 cause mental retardation syndromic X-linked Stocco dos Santos type; several SHROOM4 translocations cause X-linked mental retardation.
References in periodicals archive ?
metabolism (B3GALT6, BHMT2, KMO, LIPC, MDH1B, NPL, SMC3), cytoskeleton (SHROOM4, DNASE1, TBCD), signal transduction (ADRBK2, ARF1, CLSTN2, DLGAP2, GPRC5C, GUK1, PTAR1, RABGGTB, WNT10A, ZNF544), transcriptional regulation (HAT1, JMJD5, PCGF6, ZNF599), RNA processing (DDX1, MRPS9, RPL31, SNRNP200,), protein turnover (HSPA9, PSMG4, PSKH1, RNF181, RNGTT, WDR20), as well as other or unknown functions (ABI3BP, C12orf42, CXCL6, DNASE1, LOC401098, LOC729059, LOC727973, PCDHG, REEP2, TF, SAA1, SAA4, SMPD4, STARD7, TSN, VCAM1).