SHROOM3

SHROOM3

A gene on chromosome 4q21.1 that encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins, which may be involved in regulating cell shape. A homologue in mice is required for proper neurulation.
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Many loci have been identified, including FTO (Hubacek et al., 2012); ACTN4, TRPC6, INF2, UMOD, MHC, PLA2R1/sPLA2, complement factors, APOL1 (Friedman & Pollak, 2011); and GATM/SPATA5L1 and SHROOM3 (Li, 2015).
These imply future studies in relation to the analysis of apoptosis pathways in mesenchymal stem cells [41] and regulation of genes that have been related to NTD as SHROOM3 and can be sensitive to the action of glycoalkaloids during critic periods of embryogenesis [48, 49] and the study of structural changes of the cytoskeleton induced by different concentrations of [alpha]-solanine [50].
(24.) McGreevy, E.M., et al., Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure.