SHH


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SHH

A gene on chromosome 7q36 that encodes a protein central in early embryonic patterning and the key inductive signal in patterning of the anterior-posterior limb axis, the ventral somites and the ventral neural tube.

Molecular pathology
Defects in SHH or in its signalling pathway cause holoprosencephaly, VACTERL syndrome; mutation upstream of SHH disrupts limb patterning and can result in preaxial polydactyly.
References in periodicals archive ?
increases in the SHM game and decreases in the SHL game, while not changing in the SHH game.
A strip of Shh DNA (this, of course, is an abbreviated version of the true gene, containing only a single exon; see Appendix 1)
HATS OFF: Huddersfield University student Mike Foy has launched Shh.
When they stimulated Shh production on both sides, not just the left, they saw that the newly formed heart tubes--which usually loop to the right--opted to curl to the left half of the time.
In addition, clinical trials of Shh-blocking drugs already under investigation for other cancers could begin within the next couple of years in patients with the medulloblastoma subtype driven by Shh mutations.
Similarly, blocking the cell signaling pathway designated as Hh in the Xenopus frog or in zebrafish, results in two mirror image front halves and suggests that Shh signaling is necessary for patterning the back half.
Now SHH is look for volunteers to research and keep an eye on historical items and for companies to adopt medium to large historical objects.
The Perfume Shop also withdrew Jade's perfume, Shh.
These positive results are consistent with previously published third-party data in which upregulation of the Shh pathway were demonstrated to be efficacious.
Gilbertson led the team that in 2006 showed medulloblastoma could be categorized based on whether the WNT, the SHH or another biochemical pathway was abnormally activated.
SHH, a double act from Buenos Aires have managed to make a 2010 electro equivalent.