SHC1

(redirected from SHC (Src homology 2 domain containing) transforming protein 1)

SHC1

A gene on chromosome 1q21 that encodes a widely expressed signalling adapter protein which couples activated growth factor receptors to signalling pathways. SHC1 participates in a signalling cascade initiated by activated KIT and KITLG/SCF. Once phosphorylated, the isoforms p46Shc and p52Shc couple activated receptor tyrosine kinases to Ras by recruiting the GRB2/SOS complex, leading to the cytoplasmic (i.e., non-neuronal) propagation of mitogenic signals; isoform p66Shc regulates the cellular response to oxidative stress and plays a role in stress-activated p53’s ability to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. SHC1 participates in signalling downstream of the angiopoietin receptor TEK/TIE2, and it plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. It is expressed in neural stem cells, but absent in marure neurons.