SAMSN1(redirected from SH3-SAM adaptor protein)
SAMSN1A gene on chromosome 21q11 that encodes a protein which downregulates B-cell activation and cell proliferation. It upregulates RAC1-dependent membrane ruffle formation and reorganisation of the actin cytoskeleton and HDAC1 activity. SAMSN1 regulates cell spreading, cell polarisation and LYN activity by modulating its tyrosine phosphorylation; it is upregulated in B cells by IL4, IL13 and by CD40, and it interacts with CTTN, FASLG, HDAC1, SAP30, SFN, YWHAB, YWHAE, YWHAG, YWHAH and YWHAZ.
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