SH2 domain


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SH2 domain

A modular, circa-100-amino acid domain which binds to specific phospho-containing peptide motifs; SH2 is found in adaptors, kinases, phosphatase, Ras signalling, scaffolds, transcription, ubiquination. It is involved in cytoskeletal regulation, phospholipid second messenger signalling, and in signal regulation.
References in periodicals archive ?
For identification of the phosphotyrosine binding SH2 domain and demonstrating its function in protein-protein interactions
JAK2 has no SH2 domain (binding phosphorylated tyrosine residue) or SH3 domain (binding proline-rich domain).
The SH2 domain of STAT binds to the tyrosine phosphorylated GHR cytoplasmic sites on either the GHR (STAT5a and 5b) or JAK2 (STAT1 and STAT3) (Yi et al.
This pathway begins with binding of the SHC adaptor protein via its SH2 domain to the tyrosine phosphorylated GHR (Moutoussamy et al.
All these SOCS proteins have a central SH2 domain and a conserved C-terminal region (SOCS box).
mDab1, when tyrosine phosphorylated, binds to the SH2 domain of Src, Abl and Fyn.
Throughout 2001, AxCell made continued progress in mapping PDZ, SH3, and SH2 domain families.
Harrison has made important contributions to the field of structural biology most notably in the high resolution structures of several pathogenic viruses, including the high resolution structures of HIV reverse transcriptase; CD4, the cellular receptor for HIV; and the SH2 domain, a key component of intracellular signaling pathways.
Small-Molecule Compounds That Target SH2 Domains of Signaling Proteins
SH2 domains have been associated with cancer, osteoporosis, autoimmune disorders, and allergic diseases.