SH2 domain


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SH2 domain

A modular, circa-100-amino acid domain which binds to specific phospho-containing peptide motifs; SH2 is found in adaptors, kinases, phosphatase, Ras signalling, scaffolds, transcription, ubiquination. It is involved in cytoskeletal regulation, phospholipid second messenger signalling, and in signal regulation.
References in periodicals archive ?
de/) analysis showed that pCISH contained a SH2 domain (80-169AA), a SOCS domain (210-251AA) and a SOCS_box domain (216-250AA).
Fimrther analysis showed thac pCISH contamed a SH2 domain (80-169AA) and a SOCS domain (210-251AA).
The third pathway, the MAP-kinase dependent, starts when Grb2 attaches Shc or IRS to the SH2 domain of the Grb2 protein, which is attached to Son of Sevenless (SOS), a small nucleotide exchange protein that catalyzes guanosine di-phosphate (GDP) exchange by guanosine tri-phosphate (GTP) in the protein found in the internal surface of the plasma membrane called Ras--such also favors Raf phosphorylation in serine/threonine sites.
mDab1, when tyrosine phosphorylated, binds to the SH2 domain of Src, Abl and Fyn.
Throughout 2001, AxCell made continued progress in mapping PDZ, SH3, and SH2 domain families.
Because a GST fusion protein containing an SH2 domain of Fyn can bind to PECAM-1 but an SH3 domain of Fyn cannot, the SH2 domain of cSrc appears to be involved in c-Src binding to tyrosine-phosphorylated PECAM-1.
performed pull-down assays using GST-Src-SH2 fusion proteins, revealing an interaction between MVP and the SH2 domain of Src in human stomach tissue and 253J stomach cancer cells.
JAK2 has no SH2 domain (binding phosphorylated tyrosine residue) or SH3 domain (binding proline-rich domain).
49) The CagA-SHP2 complex formation is mediated via the interaction between tyrosine-phosphorylated EPIYA-C or EPIYA-D segment and the SH2 domains of SHP2.
The GM domain region has a sequence homology from all Grb7 family proteins that contains a pleckstrin homology (PH) domain, a Ras-association domain and a functional region called BPS, which is localized between the PH and SH2 domains.
Small-Molecule Compounds That Target SH2 Domains of Signaling Proteins
We have previously established the use of small engineered antibody mimics, termed monobodies, to potently and specifically target intracellular protein-protein interactions mediated by the SH2 domains of oncogenic kinases and phosphatases.