SGK3

SGK3

A gene on chromosome 8q12 that encodes a serine/threonine-protein kinase involved in regulating various ion channels and membrane transporters involved in cell growth, survival and proliferation. It is highly expressed in the pancreas, kidneys, liver, heart and brain.

SGK3 upregulates:
• Na+ channels—e.g., SCNN1A/ENAC and SCN5A;
• K+ channels—e.g., KCNA3/Kv1.3, KCNE1, KCNQ1 and KCNH2/HERG;
• Amino acid transporters—e.g., SLC1A5/ASCT2 and SLC6A19;
• Epithelial Ca2+ channels—e.g., TRPV5 and TRPV6;
• Chloride channel—e.g., BSND
• Creatine transporter—e.g., SLC6A8;
• Glutamate transporter—e.g., SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5;
• Glutamate receptors—e.g., GRIA1/GLUR1 and GRIK2/GLUR6;
• Na+-dependent phosphate cotransporter—e.g., SLC34A2/NAPI-2B;
• Na+/dicarboxylate cotransporter—e.g., SLC13A2/NADC1;
• Na+/H+ exchanger—e.g.,  SLC9A3/NHE3; and
• Na+/K+ ATPase.
References in periodicals archive ?
2013;452:499-508 http://www.biochemj.org/bj/452/0499/bj4520499.htm and Bago, R et al., Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.
Cohen et al., "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel [alpha], [beta], [gamma]-ENaC," Pflugers Archiv European Journal of Physiology, vol.