SGK1

A gene on chromosome 6q23 that encodes serum/glucocorticoid-inducible kinase 1, a serine/threonine protein kinase that activates certain K+, Na=, and Cl- channels in response to cell stress, and which appears to be involved in cell survival, neuronal excitability and renal sodium excretion. It is highly expressed in hypertension and diabetic nephropathy.

References in periodicals archive ?

Arsenic inhibits SGK1 activation of CFTR Cl- channels in the gill of killifish, Fundulus heteroclitus.

Advancing toxicology research using in vivo high throughput toxicology with small fish models

17) The salt-induced TH17 cell development is inhibited through gene silencing or chemical inhibition of NFAT5, SGK1 or p38/MAPK (Kleinewietfeld, et al.

Salt and autoimmune disease; Review of studies

Sixteen significantly mutated genes were discerned in this molecular subgroup (Table 1): 9 genes previously implicated in endometrial cancer (PTEN, PIK3CA, CTNNB1, ARID1A, PIK3R1, KRAS, FGFR2, CHD4, SPOP) by us and others [(17, 18); reviewed in (24)], and 7 genes (BCOR, CSMD3, CTCF, MECOM, METTL14, SGK1, SOX17) not previously recognized to have a role in endometrial tumorigenesis.

The emerging genomic landscape of endometrial cancer

Arsenic inhibits SGK1 activation of CFTR Cl-channels in the gill of killifish, Fundulus heterociitus.

Early life arsenic exposure and acute and long-term responses to influenza A infection in mice

They discovered that a protein called SGK1 prolonged cortisol's harmful effects, and that blocking SGK1 with a drug known to obstruct the protein significantly reduced the brain changes caused by stress hormones, promoting neurogenesis.

Scientists block gene behind stress-related damage to brain

cerevisiae) and SGK1 (serum/glucocorticoid regulated kinase 1) (Figure 4).

Microarray analysis of genes involved with shell strength in layer shell gland at the early stage of active calcification

They identified a specific gene known as SGK1 that plays an important role in the cells' development.

Excess salt may trigger autoimmune disorders

Professor Jan Brosens, of Warwick Medical School, believes the enzyme SGK1 is a natural "fertility switch".

Breakthrough discovery at med school

High levels of a protein called SGK1 can cause infertility but when there is not enough women are more likely to lose a baby.

FERTILITy HOpE

The researchers discovered that the womb lining in these women had high levels of the enzyme SGK1.

'Fertility switch' that can stop pregnancy and cause miscarriage identified

Among the 9 genes analyzed in human blood samples, the expression of 6 genes, namely, BHLHB2, CCNL1, SE20-4, C8FW, PLK2, and SGK1, was significantly higher in the high-TZCA group than in the low-TZCA group.

Identification of gene markers for formaldehyde exposure in humans

In the second 10-min step, the activated SGK1 phosphorylates a synthetic peptide (RPRAATF) using [[gamma]-[.

Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid