SETX

SETX

A gene on chromosome 9q34 that encodes a protein homolous to fungal Sen1p protein which has RNA helicase activity, and which is thought to be involved in RNA and DNA processing and repairing breaks in double-stranded DNA caused by oxidative damage.

Molecular pathology
SETX mutations have been linked to ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4).
References in periodicals archive ?
Case in point, exome sequencing in a patient suspected with mitochondrial disease revealed a homozygous splice site mutation in SETX, which is known to cause Spinocerebellar Ataxia, Autosomal Recessive 1 (SCAR1).
21, 35, and 36) presented mutations in SETX (senataxin), ZFYVE26 (zinc finger, FYVE domain containing 26), and SACS, respectively.
CitX has developed a unique transaction transport technology called SETX to provide the end-to-end security, scalable processing capability of Electronic Commerce transactions.