SETD7

SETD7

A gene on chromosome 4q28 that encodes a SET domain-containing histone-lysine methyltransferase that specifically monomethylates Lys-4 of histone H3, providing a specific tag for epigenetic transcriptional activation. SETD7 pays a central role in the transcriptional activation of genes encoding collagenase, insulin and other proteins; it also has methyltransferase activity toward non-histone proteins, such as p53/TP53, TAF10 and possibly TAF7. SETD7 is widely expressed, especially in pancreatic islets. It interacts with IPF1/PDX-1.
References in periodicals archive ?
Hyperglycemia can activate methyltransferase enzyme Set7/9 (SetD7), which facilitates the methylation of lysine 4 on histone 3, and increases the binding of Sp-1 to the Keap1 promoter.
On the other hand, hyperglycemia facilities methylation of the Keap1 promoter via methyltransferase enzyme Set7/9 (SetD7), which eases stimulating protein-1 (Sp-1) binding to the promoter, resulting in increased Keap1 expression; therefore, Keap1 combines with Nrf2 and represses Nrf2 in the cytosol.
Forsblom et al., "Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes," Diabetes, vol.