SETD6

SETD6

A gene on chromosome 16q21 that encodes a SET domain-containing protein-lysine N-methyltransferase that specifically monomethylates Lys-310 of the RELA subunit of NF-kappaB complex, downregulating NF-kappaB transcription factor activity.
References in periodicals archive ?
A truncating dominant negative mutation in SETD6 also provides a possible explanation for the cancer predisposition of one FCCX family [75].
Levy, "SETD6 dominant negative mutation in familial colorectal cancer type X," Human Molecular Genetics, vol.
These loci harbored two gap junction-related genes, plakophilin 2 (PKP2) and cortactin-binding protein 2 Nterminal like (CTTNBP2NL), and two neuroendocrine-related genes, SET domain containing 6 (SETD6) and calcium channel, voltage-dependent, beta 2 subunit (CACNB2).