However, other genes such as KMT2, SETD5
, or chromosome deletions such as 9q31.1-q32 deletion and 8p23.1deletion can also lead to CdLS phenotype.
We also found that in module 1, a hub lncRNA LINC00472 functioned as a hub to compete with 12 mRNAs (GATAD2B, MED13L, TSC22D1, SETD5
, HIP1, ARNTL2, HMGN3, EPAS1, RELL1, ARHGEF10, ZNF532, and CTSS) and 3 lncRNAs (HCP5, HLA-F-AS1, and BAIAP2-AS1) in a 16-ceRNA module (Figure 6A), implying its important roles in LAD.
Similarly, in the rat dataset with access number GSE2409, the selected 16 genes were RGD1309228, Ccdc21, Setd5
, RGD1303130, Vps26a, Sept2, BF396256, Adprhl2, BE109616, Phf3, Tfb2m, Lyplal1, Arg1, Ndufs2, Tmem208, and Nsun2.