SETD1A

SETD1A

A gene on chromosome 16p11.2 that encodes a histone methyltransferase which specifically methylates Lys-4 of histone H3 when it forms part of the SET1 histone methyltransferase (HMT) complex, but not if the neighbouring Lys-9 residue is not already methylated. H3 Lys-4 methylation is a specific tag for epigenetic transcriptional activation; SETD1A and SETD1B are thought to make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.
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The spheroids formed in the RWVR showed higher SI values than 2D-cultured MIN6 cells, the shape and size of spheroid cells was similar to pancreatic islets, and the expression of the genes insulin2, glucokinase, SETD1A, and Kir6.2 was stronger than in MIN6 cells from 2D cultures [92].
They were able to verify two key damaging mutations in a gene called SETD1A, suggesting that this gene contributes significantly to the disease.
SETD1A is involved in a process called chromatin modification.