SETD1A | definition of SETD1A by Medical dictionary
SETD1A A gene on chromosome 16p11.2 that encodes a histone methyltransferase which specifically methylates Lys-4 of histone H3 when it forms part of the SET1 histone methyltransferase (HMT) complex, but not if the neighbouring Lys-9 residue is not already methylated. H3 Lys-4 methylation is a specific tag for epigenetic transcriptional activation; SETD1A and SETD1B are thought to make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.
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References in periodicals archive
The spheroids formed in the RWVR showed higher SI values than 2D-cultured MIN6 cells, the shape and size of spheroid cells was similar to pancreatic islets, and the expression of the genes insulin2, glucokinase, SETD1A
, and Kir6.2 was stronger than in MIN6 cells from 2D cultures .
They were able to verify two key damaging mutations in a gene called SETD1A, suggesting that this gene contributes significantly to the disease.
SETD1A is involved in a process called chromatin modification.