SETD1A

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SETD1A

A gene on chromosome 16p11.2 that encodes a histone methyltransferase which specifically methylates Lys-4 of histone H3 when it forms part of the SET1 histone methyltransferase (HMT) complex, but not if the neighbouring Lys-9 residue is not already methylated. H3 Lys-4 methylation is a specific tag for epigenetic transcriptional activation; SETD1A and SETD1B are thought to make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.
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H3K4 is methylated by the KMT2 family (MLL1, MLL2, MLL3, MLL4, MLL5, SET1A, SET1B, and ASH1L) and the KMT7 family (SET7/9) as well as SMYD3, PRDM9, and PRMT6.
Methylation of H3K4 is activated by SET-1 family enzymes SET1A, SeT1B, MILL1, MILL2, MILL3, and MILL4.
The TrxG core interacts with a group of interchangeable H3K4 methyltransferases, including some called mixed lineage leukemia (MLL) proteins (i.e., MLL1, MLL2, MLL3, and MLL4) and proteins called SET1A and SET1B (Jiang et al.