SERPING1


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SERPING1

A gene on chromosome 11q12-q13.1 that encodes a highly glycosylated plasma protein which regulates the complement cascade by inhibiting activated C1r and C1s, thereby preventing complement activation.

Molecular pathology
C1-INH/SERPING1 deficiency is associated with hereditary angioneurotic oedema (HANE).
References in periodicals archive ?
445] reactive center of SERPING1, thereby simplifying the sequencing strategy.
Andrew Lotery, Professor of Ophthalmology at the University of Southampton, said: "Our study also shows that a particular variant of the gene SERPING1 carried by just under a quarter of the population appears to offer some protection against the disease.